"George Bush doesn't care about beavers!" - Refers to Kanye West saying that "George Bush doesn't care about black people" during a September 2 Katrina relief concert.
The Grocery Mart now present in town has the look of the Wall*Mart that self-destructed in "Something Wall*Mart This Way Comes".

Yes, the man with the shopping cart full of beer is a parody of the black man wading through the flood after Hurricane Katrina with a bucket full of beer. He's known as the Beer Looter Dude and the Looter Guy, Hurricane Hero.
Mr. Derp appears going off to his left as everyone clears out of the school. A younger nurse appears as well, but one or two frames show Nurse Gollum up close.

Mrs. Garrison couldn't fool anyone now. Sheila refers to her as her old self, Mr. Garrison.
The exaggerated numbers reflect the number of feared dead versus the number of actual dead found in the aftermath of Katrina. Ten thousand body bags were ordered for New Orleans, only 800 or so bodies were found there. Same with 9/11 - up to 50,000 people were feared dead when the towers came down, but the actual number of fatalities was about 3300. And there's no way temperatures could drop to 70 million degrees below zero. Absolute zero is at 0 Kelvin (0° K), which is at -273.15° Celsius or -459.67° Fahrenheit.
References to The Day After Tomorrow
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Star Trek: Generations reference: Capt. Kirk and Dr. Sorian on a failing bridge. Kirk met his demise here, as Cartman would have on the landing if he had fallen into the fire below.